Yes, the contents can be accessed and updated using Applescript
From Devonthink’s script dictionary; record properties include

The script would be something like this
tell application id "DNtp" --------------------------Retrieve the DT data
set theDailyNote to (get record with uuid "0538FAFE-BCDE-448C-8BDE-13E875EF34B0")
set theNewContents to "..."
set plain text of theDailyNote to theNewContents
end tell